{"product_id":"abcam-ab237813","title":"Abcam, ab237813, Anti-CYB5R2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal CYB5R2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CYB5R2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human CYB5R2.Q6BCY4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe CYB5R2 target also known as cytochrome b5 reductase 2 functions as an enzyme involved in electron transfer processes. It catalyzes the reduction of cytochrome b5 using NADH as an electron donor playing a critical role in the redox reactions. The molecular mass of CYB5R2 is approximately 34 kDa. This protein shows expression in multiple tissues including the liver and testis which suggests its widespread importance in cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCytochrome b5 reductase 2 facilitates fatty acid desaturation and elongation. This protein does not function alone but often participates as part of larger enzyme complexes. In particular CYB5R2 operates in electron transport processes that are essential for maintaining cellular oxidation-reduction balance. Its activity in these processes highlights its role in maintaining metabolic homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nCYB5R2 engages in fatty acid metabolism and lipid biosynthesis pathways. The protein collaborates with cytochrome P450 enzymes to contribute to lipid modification. These pathways play fundamental roles in energy storage and membrane structure which are necessary for cell function and survival. CYB5R2 shows interactivity with proteins such as CYB5A highlighting the intricate network of cellular electron transport.\u003cbr\u003e\nMutations or dysregulation in cytochrome b5 reductase 2 have associations with methemoglobinemia and certain cancers. Methemoglobinemia emerges due to the inability to effectively reduce methemoglobin to hemoglobin causing inefficient oxygen delivery to tissues. The connection with CYB5R2 in this disease involves its critical function in electron transfer. Additionally research indicates links between variations in CYB5R2 and prostate cancer emphasizing its role in cellular growth and proliferation alongside interactions with other proteins such as CYB5A.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854349947049,"sku":"ab237813","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab237813","provider":"Iright","version":"1.0","type":"link"}