{"product_id":"abcam-ab238646","title":"Abcam, ab238646, Anti-DPEP3 antibody [EPR21862] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal DPEP3 antibody. Carrier free. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR21862,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab238646 is the carrier-free version of\u003cbr\u003e\nab235451\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDipeptidase 3 (DPEP3) also known as MBD-2 or membrane-bound dipeptidase 3 is an enzyme that performs important roles in hydrolyzing dipeptides. DPEP3 has a molecular weight of approximately 52 kDa. It belongs to the dipeptidase family and is often found in the membranes of the kidney and testis where it contributes to peptide metabolism. As a metalloprotease DPEP3 requires a metal ion as a cofactor for its catalytic activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDPEP3 contributes to diverse physiological processes in the body. This enzyme often exists as a part of a multi-protein complex facilitating the breakdown of dietary peptides and the renal processing of glutathione and leukotriene D4. Through its enzymatic action DPEP3 helps in managing extracellular matrix homeostasis and detoxifying a wide range of substances that circulate in the body.\u003cbr\u003e\nPathways\u003cbr\u003e\nDPEP3 influences several metabolic pathways by engaging in the breakdown of dipeptides. Of particular note DPEP3 functions within the leukotriene metabolism and glutathione metabolism pathways. In leukotriene metabolism enzymes such as leukotriene A4 hydrolase collaborate with DPEP3 for the conversion of leukotrienes into biologically active lipid mediators. In the glutathione metabolism pathway DPEP3's activity is augmented by its interaction with glutathione S-transferases.\u003cbr\u003e\nDPEP3 shows relevance to conditions like renal dysfunctions and allergic responses. The enzyme's role in metabolizing leukotrienes links it to asthma and other allergic conditions where dysregulated leukotriene pathways play a part. Furthermore changes in DPEP3 expression might be observed alongside alterations in the activity of glutathione S-transferases which could impact renal health and lead to disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851815964841,"sku":"ab238646","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab238646","provider":"Iright","version":"1.0","type":"link"}