{"product_id":"abcam-ab238740","title":"Abcam, ab238740, Anti-TMEM2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TMEM2 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CEMIP2 aa 700-900.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human CEMIP2 aa 700-900. The exact immunogen used to generate this antibody is proprietary information.Q9UHN6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTMEM2 also known as Transmembrane Protein 2 is a protein involved in the hydrolysis of hyaluronan a component of the extracellular matrix. TMEM2 is a single-pass type II transmembrane protein with a molecular mass of approximately 150 kDa. It is expressed in various tissues with heightened expression in the heart skeletal muscle and connective tissues. Researchers have noted its importance in the remodeling of the matrix during developmental processes and tissue repair.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein TMEM2 plays a role in hyaluronan turnover which affects processes like cell motility and proliferation. It is not part of a larger protein complex but its activity influences the availability of hyaluronan fragments that interact with other cell surface receptors. This interaction can influence cellular responses such as inflammation and tissue modeling.\u003cbr\u003e\nPathways\u003cbr\u003e\nTMEM2 is significant in the matrix degradation pathway impacting cellular and tissue development signaling. It is related to the extracellular matrix organization pathway where its function in hyaluronan degradation directly affects other matrix proteins. This interaction is often seen with proteins such as CD44 and RHAMM which are known to bind hyaluronan fragments and mediate further signaling.\u003cbr\u003e\nTMEM2 mutations or dysfunctions have links to cardiovascular diseases and certain cancers. Its role in hyaluronan turnover has implications in pathological processes like tumor metastasis given that altered extracellular matrix can affect cancer cell mobility. The protein interacts with CD44 a receptor involved in tumor progression and metastasis highlighting its potential importance in oncological research. Understanding TMEM2 and its pathways could provide insights into therapeutic targets for treating cancer and cardiovascular conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854089638057,"sku":"ab238740","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab238740","provider":"Iright","version":"1.0","type":"link"}