{"product_id":"abcam-ab240569","title":"Abcam, ab240569, Anti-MTMR1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal MTMR1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human MTMR1 aa 600 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human MTMR1 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q13613\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab240569 was affinity purified using an epitope specific to MTMR1 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMTMR1 also known as Myotubularin-related protein 1 belongs to the myotubularin family of phosphatidylinositol (PI) phosphatases. It plays a role in regulating phosphoinositide levels. The protein has a molecular mass of approximately 72 kDa. Scientists have found its expression in various tissues including skeletal muscle and the nervous system. MTMR1 is important for cellular homeostasis by modulating lipid signaling pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein functions as a phosphatase that removes phosphate groups from phosphatidylinositol 3-phosphate and phosphatidylinositol 35-bisphosphate. It does not work alone but as part of complexes that include other proteins from the same family. This collaboration allows for regulating PI levels which are involved in membrane trafficking and signal transduction. Its activity impacts cellular processes like endocytosis and autophagy which are important for cell maintenance and survival.\u003cbr\u003e\nPathways\u003cbr\u003e\nMTMR1 is involved in pathways that include lipid signaling and autophagy. It particularly affects the PI3K-Akt signaling pathway which is important for controlling cell growth and apoptosis. MTMR1 can interact with other members of the myotubularin family like MTMR2 to execute its functions in these pathways. The interconnected work of these proteins ensures the correct functioning of signal transduction and cellular homeostasis.\u003cbr\u003e\nMTMR1 has connections with muscular and neurological diseases. Particularly its dysfunction has been noted in types of muscular dystrophy. Researchers have linked its activity with proteins such as MTMR13 showing combined roles in disease mechanisms especially those affecting muscle tissue. Studies continue to explore these associations to understand better and manage related disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854021087401,"sku":"ab240569","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab240569","provider":"Iright","version":"1.0","type":"link"}