{"product_id":"abcam-ab240974","title":"Abcam, ab240974, Anti-RAB7B antibody [EPR15727] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal RAB7B antibody. Carrier free. Suitable for WB, Flow Cyt (Intra), IHC-P and reacts with Mouse, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15727,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab240974 is the carrier-free version of\u003cbr\u003e\nab193360\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRAB7B also known as Ras-related protein Rab-7b is a small GTPase belonging to the Ras superfamily. This protein weighs approximately 23 kDa. Researchers find RAB7B in various tissues including the immune and the central nervous system. It plays a direct role in intracellular protein trafficking and vesicular transport moving proteins and other molecules from one organelle to another within cells. Through its association with specific membrane compartments RAB7B assists in maintaining the dynamic balance of vesicle budding transport and fusion regulating endosomal sorting.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe functions of RAB7B include its contribution to lysosomal biogenesis and endosome-to-lysosome trafficking. It is part of a complex known as the endosomal transport modulation machinery where it interacts with multiple effector proteins to translocate cargo to the lysosome for degradation or recycling. In immune cells RAB7B helps modulate immune response by controlling the degradation of signaling receptors. This function makes it essential for cellular homeostasis and adaptive immune responses influencing antigen processing.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe interaction of RAB7B with other members of the Rab GTPase family situates it in important cellular pathways like the endocytic pathway and autophagy. In the endocytic pathway it coordinates with proteins like RAB5A transitioning early endosomes to late endosomes. The action in autophagy involves interaction with other autophagic regulators to aid in autophagosomal-lysosomal fusion influencing how cells handle stress and remove damaged components.\u003cbr\u003e\nAbnormal RAB7B expression has been linked to neurodegenerative diseases like Alzheimer's and immune disorders such as rheumatoid arthritis. Its interaction with other proteins like LRRK2 in Parkinson's disease implicates it in pathways that lead to neuronal damage and inflammation. In rheumatoid arthritis RAB7B influences immune cell signaling and cytokine release contributing to autoimmune responses. Understanding its associations aids in developing therapeutic strategies targeting the molecular functions of RAB7B in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851811999913,"sku":"ab240974","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab240974","provider":"Iright","version":"1.0","type":"link"}