{"product_id":"abcam-ab241406","title":"Abcam, ab241406, Anti-Roquin-2 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal Roquin-2 antibody. Suitable for IP and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human RC3H2 aa 900-950.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human RC3H2 aa 900-950. The exact immunogen used to generate this antibody is proprietary information.Q9HBD1\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab241406 has not performed satisfactorily when used for WB of Roquin-2 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of Roquin-2.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab241406 was affinity purified using an epitope specific to Roquin-2 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRoquin-2 also known as RC3H2 is a protein recognized for its role in post-transcriptional regulation. The protein has a mass of approximately 125 kilodaltons. You can find Roquin-2 primarily expressed in immune cells such as T-cells and B-cells but it is also present in other tissues. It contains a RING finger domain that allows it to function as an E3 ubiquitin ligase. This domain plays an important role in protein-protein interactions and tagging other proteins for degradation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRoquin-2 regulates the stability and translation of several mRNAs involved in inflammatory responses. Acting as a post-transcriptional modulator Roquin-2 binds to specific sequences in the 3' untranslated region (UTR) of target mRNAs affecting their degradation or translation. Roquin-2 is part of a larger complex that includes other regulatory proteins allowing for precise control over mRNA fate. This control impacts various immune functions which is vital for maintaining immune homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearch has shown that Roquin-2 integrates into the immune response pathways. It has significant involvement in the NF-κB signaling pathway where it modulates the production of cytokines. Roquin-2 also interacts with the TTP protein which is another post-transcriptional regulator highlighting its role in inflammation-related pathways. These interactions influence gene expression patterns that are necessary for appropriate immune functions.\u003cbr\u003e\nCurrent studies indicate Roquin-2 has implications in autoimmune diseases such as systemic lupus erythematosus. Alterations in Roquin-2 function can lead to dysregulated immune responses contributing to such disorders. Roquin-2 is connected to proteins involved in autoimmune pathways including ICOS which plays a role in T-cell activation. Understanding how Roquin-2 controls these pathways could offer insights into therapeutic approaches for autoimmune conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853931925673,"sku":"ab241406","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab241406","provider":"Iright","version":"1.0","type":"link"}