{"product_id":"abcam-ab245556","title":"Abcam, ab245556, Anti-INF2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal INF2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human INF2 aa 950-1000.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human INF2 aa 950-1000. The exact immunogen used to generate this antibody is proprietary information.Q27J81\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab245556 was affinity purified using an epitope specific to INF2 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe INF2 protein officially named Inverted Formin 2 is involved in actin dynamics. It has a mass of approximately 139 kDa. INF2 exists throughout many tissues in the body with high expression in the kidney brain and heart. This protein structurally influences filamentous actin (F-actin) and globular actin (G-actin) balance facilitating cytoskeleton remodeling and cell shape changes. With these functions INF2 can take on different roles depending on cell type and physiological conditions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nInverted Formin 2 acts in multiple cellular processes like cell migration and division. It is a part of the formin family of proteins which are known to regulate actin filament polymerization. INF2 forms complexes with other proteins including mitochondria-associated membranes (MAMs). It connects the endoplasmic reticulum to mitochondria which supports cellular activities like calcium ion transfer and lipid biosynthesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nINF2 interacts with the Rho family GTPases in the regulation of actin cytoskeleton dynamics. It plays important roles in the RhoA pathway assisting the polymerization and depolymerization of actin filaments which impacts cell movement and morphology. INF2 interacts with diaphanous-related formins (DRFs) including mDia1 to support these cellular functions.\u003cbr\u003e\nAbnormal regulation or mutation of INF2 can lead to serious conditions as shown in focal segmental glomerulosclerosis (FSGS) and Charcot-Marie-Tooth (CMT) disease. Mutations in INF2 causing defective protein interactions can trigger renal pathology by impairing the podocyte cytoskeleton. The connection with nephrin another protein critical for kidney function highlights further implications for FSGS. In neuromuscular disorders like CMT altered dynamics between INF2 and dynamin-related mitochondrial protein (DRP1) affect mitochondrial fission leading to axonal degeneration.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853985697961,"sku":"ab245556","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab245556","provider":"Iright","version":"1.0","type":"link"}