{"product_id":"abcam-ab246928","title":"Abcam, ab246928, Anti-ALDH1B1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal ALDH1B1 antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ALDH1B1 aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ALDH1B1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.P30837\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe enzyme ALDH1B1 also known as aldehyde dehydrogenase 1 family member B1 plays a critical role in converting aldehydes to their corresponding carboxylic acids. ALDH1B1 possesses a molecular mass of approximately 56 kDa. This enzyme is expressed in various tissues with particular abundance in the liver and the gastrointestinal tract where it facilitates the detoxification and metabolism of aldehydes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis enzyme participates in the oxidation of aldehydes derived from alcohol metabolism enhancing cellular resilience by minimizing toxic aldehyde accumulation. ALDH1B1 occasionally acts as part of larger enzyme complexes where it collaborates with other members of the aldehyde dehydrogenase family to maintain cellular homeostasis and aid in metabolic processes. The enzyme ensures efficient functioning of aldehyde detoxification systems contributing to cellular health.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis enzyme is integral to the ethanol metabolism pathway and the one-carbon metabolism pathway. In the ethanol metabolism pathway ALDH1B1 complements other aldehyde dehydrogenase enzymes like ALDH2 converting acetaldehyde to acetate and facilitating safe excretion. In one-carbon metabolism ALDH1B1 influences folate cycle components potentially impacting methylation processes and folate-dependent synthesis pathways. These pathways highlight the enzyme’s role in protecting cells from aldehyde-induced toxicity and maintaining metabolic balance.\u003cbr\u003e\nALDH1B1 has been linked to alcohol-related liver disease where its dysfunction may impair acetaldehyde clearance contributing to tissue damage and inflammation. Furthermore abnormal ALDH1B1 activity is associated with colorectal cancer implicating disrupted aldehyde detoxification in tumorigenesis. The enzyme's interaction with proteins such as ALDH2 in these conditions highlights its importance in regulating cellular and tissue health in response to metabolic and alcohol-induced stresses.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860510265513,"sku":"ab246928","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab246928","provider":"Iright","version":"1.0","type":"link"}