{"product_id":"abcam-ab247787","title":"Abcam, ab247787, Anti-PIP5K1C antibody [MAO-R1] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PIP5K1C antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:MAO-R1,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab247787 is the carrier-free version of\u003cbr\u003e\nab109192\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein PIP5K1C also known as phosphatidylinositol-4-phosphate 5-kinase type-1 gamma has a mass of approximately 75 kDa. This enzyme plays a critical role in the phosphatidylinositol signaling pathway where it catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PI4P) to produce phosphatidylinositol 45-bisphosphate (PIP2). PIP5K1C's activity is pivotal for membrane trafficking and it demonstrates widespread expression in tissues including the brain and skeletal muscle.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPIP5K1C is involved in the regulation of actin cytoskeleton dynamics. It participates as an important enzyme in complexes that modulate actin polymerization and cell adhesion processes. Its function impacts cell motility and maintenance of cell shape contributing significantly to endocytosis and exocytosis. This function highlights the enzyme's role in intracellular signaling and adhesion-related activities.\u003cbr\u003e\nPathways\u003cbr\u003e\nPIP5K1C interacts intricately within the phosphoinositide signaling pathway and impacts the regulation of focal adhesion. It influences other proteins like RAC1 an important regulator of actin polymerization and talin which is involved in linking integrins to the actin cytoskeleton. These interactions place PIP5K1C as an important contributor to the molecular mechanisms that control cell movement and attachment.\u003cbr\u003e\nMutations or dysfunctions in PIP5K1C have been associated with neurological disorders such as Charcot-Marie-Tooth disease type 4F and L-fucosidosis. Abnormalities in PIP5K1C expression or activity can disrupt cellular functions and lead to these conditions. In the context of Charcot-Marie-Tooth disease PIP5K1C may interact with dynamin 2 a protein involved in endocytic vesicle fission which further influences the peripheral nervous system pathology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46856369897641,"sku":"ab247787","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab247787","provider":"Iright","version":"1.0","type":"link"}