{"product_id":"abcam-ab248225","title":"Abcam, ab248225, Anti-HGFA Inhibitor 2 antibody [EPR6283(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal HGFA Inhibitor 2 antibody. Carrier free. Suitable for ICC\/IF, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR6283(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248225 is the carrier-free version of\u003cbr\u003e\nab128926\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHGFA Inhibitor 2 also known as HAI-2 is a serine protease inhibitor involved in regulating the activity of hepatocyte growth factor activator (HGFA). The approximate molecular mass of HAI-2 is 54 kDa. This inhibitor is widely expressed in many tissues but shows especially high expression in the epithelial tissues including the liver kidney and gastrointestinal tract. It often acts near sites of tissue injury or regeneration due to its role in controlling proteolytic activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHGFA Inhibitor 2 is involved in the control of protease-mediated signaling pathways by functioning as a member of a protease inhibitor complex. It plays a role in modulating the activity of proteolytic enzymes which influence tissue remodeling cell growth and angiogenesis. By inhibiting HGFA HAI-2 regulates the conversion of inactive hepatocyte growth factor (HGF) into its active form therefore controlling processes that are important for epithelial cell dynamics.\u003cbr\u003e\nPathways\u003cbr\u003e\nHGFA Inhibitor 2 contributes to the HGF\/c-Met signaling pathway and impacts the plasminogen activation system. Through the regulation of HGFA HAI-2 inadvertently influences the activation of c-Met a receptor tyrosine kinase. This interaction is key for numerous processes including cell proliferation motility and morphogenesis. Additionally by affecting the plasminogen activation cascade it helps to modulate extracellular matrix degradation and cellular migration through its association with proteins like uPA and plasminogen.\u003cbr\u003e\nHGFA Inhibitor 2 relates to conditions such as cancer and chronic kidney disease. It is significant in cancer biology due to its influence on tumor growth and metastasis given its role in the activation of the HGF\/c-Met pathway frequently implicated in various cancers. In chronic kidney disease the dysregulation of HAI-2 can disrupt normal protease activity affecting kidney function and potentially contributing to disease progression. Related proteins in these contexts include HGFA and c-Met which are involved in the alteration of cellular behavior in these pathologies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851835953321,"sku":"ab248225","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab248225","provider":"Iright","version":"1.0","type":"link"}