{"product_id":"abcam-ab248296","title":"Abcam, ab248296, Anti-Sulfite oxidase antibody [EPR7618] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Sulfite oxidase antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7618,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248296 is the carrier-free version of\u003cbr\u003e\nab129094\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSulfite oxidase also known as SUOX has a molecular mass of approximately 57 kDa and plays a critical role in the conversion of sulfite to sulfate. This enzyme is located in the mitochondria of cells across various tissues but is prominently expressed in the liver and kidney. Its activity depends on molybdenum and heme cofactors rendering it an important player in cellular redox reactions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSulfite oxidase acts in the detoxification process of sulfur-containing amino acids. It functions as a monomer and ensures that the potentially harmful intermediate sulfite is efficiently converted to the harmless end product sulfate which can then be excreted. This detoxification is important for cellular health and prevents accumulation of sulfite which could lead to oxidative damage.\u003cbr\u003e\nPathways\u003cbr\u003e\nSulfite oxidase plays an important part in two major metabolic processes: the sulfur amino acid detoxification pathway and the metabolic pathway of the degradation of branched-chain amino acids. It works together with cytochrome c in the electron transport chain to facilitate electron transfer. Sulfite oxidase’s function ensures proper catabolism of amino acids and assists in maintaining cellular homeostasis.\u003cbr\u003e\nSulfite oxidase deficiency can cause severe neurological impairment and developmental delay often linked to sulfite oxidase deficiency disorder itself. This genetic disorder results from mutations in the SUOX gene disrupting proper enzyme function. Associations have also been highlighted with neurological conditions where oxidative stress plays a part implicating this enzyme’s failure to properly regulate sulfite levels. Additionally its interactions with the molybdenum cofactor highlight connections to molybdenum cofactor deficiency further illustrating its importance in human health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851271000233,"sku":"ab248296","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab248296","provider":"Iright","version":"1.0","type":"link"}