{"product_id":"abcam-ab248313","title":"Abcam, ab248313, Anti-PFDN5 antibody [EPR7755] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PFDN5 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7755,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab248313 is the carrier-free version of\u003cbr\u003e\nab129116\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Prefoldin Subunit 5 (PFDN5) also known as PFD5 or MKBP is a protein that forms part of the prefoldin complex. This protein which has a mass of around 15.7 kDa plays an important mechanical role in delivering nascent polypeptide chains to the chaperonin complex for proper folding. PFDN5 is expressed widely across various tissues with notable expression in the brain and testis. Its involvement in such fundamental processes suggests it supports maintaining cellular stability and homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPFDN5 contributes to the assembly and stabilization of cytoskeletal structures by participating in tubulin folding processes. It functions as a component of the prefoldin complex a hexameric molecular chaperone. Through its action PFDN5 assists in the folding and assembly of cytoskeletal proteins such as actin and tubulin ensuring proper cellular architecture and transport functions. The protein’s interaction within the complex highlights its support in cellular dynamics and structural maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nPFDN5 integrates into important cellular pathways related to protein folding and cytoskeletal assembly. It participates prominently in the tubulin folding pathway which is essential for microtubule formation. In this context PFDN5 interacts significantly with chaperonin-containing T-complex protein 1 (CCT) to facilitate the assembly of tubulin monomers into functional microtubules. These interactions highlight PFDN5’s role in maintaining cellular integrity and facilitating intracellular transport mechanisms.\u003cbr\u003e\nPFDN5 presents associations with certain cancers particularly glioma. Altered expression or function of PFDN5 can disrupt normal cytoskeletal processes contributing to the irregular cell proliferation observed in gliomas. It has shown interactions with proteins like CCT2 in such pathological conditions. Furthermore PFDN5’s involvement in neurodegenerative processes links it to diseases like amyotrophic lateral sclerosis (ALS). In these contexts PFDN5 might influence disease progression through its impact on protein stability and cellular architecture.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851829465257,"sku":"ab248313","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab248313","provider":"Iright","version":"1.0","type":"link"}