{"product_id":"abcam-ab249002","title":"Abcam, ab249002, Anti-Dynamin 2 antibody [EPR9053(2)(ABC)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Dynamin 2 antibody. Carrier free. Suitable for IHC-P, ICC\/IF, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9053(2)(ABC),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249002 is the carrier-free version of\u003cbr\u003e\nab151555\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDynamin 2 also known as dynamin protein or DNM2 is a GTPase enzyme with a mass of approximately 100 kDa. This protein is mainly found in human cells such as fibroblasts epithelial cells and neurons. It functions by facilitating membrane fission events which are important for endocytosis and other vesicular trafficking processes. The flexible structure of dynamin-2 allows it to act as a molecular motor generating mechanical force upon GTP hydrolysis to constrict and sever membranes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDynamin 2 participates in cellular processes like receptor-mediated endocytosis and are involved in actin and microtubule dynamics. It associates with other proteins to form complexes that stabilize its function and activity within the cell. By enabling endocytosis dynamin-2 plays a role in nutrient uptake signaling and membrane recycling ensuring proper cellular function and homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nDynamin 2 is integral to the clathrin-mediated endocytic pathway and the actin cytoskeleton regulation pathway. In the clathrin-mediated pathway it interacts with clathrin and adaptin proteins to facilitate the budding and release of clathrin-coated vesicles. Within the actin cytoskeleton pathway dynamin-2 is related to actin-binding proteins which it assists in remodeling the cytoskeleton structure supporting cell shape and motility.\u003cbr\u003e\nMutations in dynamin 2 have been linked to Charcot-Marie-Tooth disease and centronuclear myopathy. These conditions affect peripheral nerves and skeletal muscles respectively and stem from dysfunction in the cellular trafficking and division processes mediated by dynamin-2. The pathology of these diseases involves connections with other proteins such as myotubularin and other muscular-associated proteins indicating the significance of dynamin-2 in maintaining normal cellular functions and its role in neuromuscular disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851778642089,"sku":"ab249002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab249002","provider":"Iright","version":"1.0","type":"link"}