{"product_id":"abcam-ab249014","title":"Abcam, ab249014, Anti-HoxC6 antibody [EPR7922(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal HoxC6 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7922(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249014 is the carrier-free version of\u003cbr\u003e\nab151575\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHoxC6 also known as Homeobox C6 is a transcription factor that guides the formation of body structure during early development. The protein weighs approximately 25 kDa and plays an important role in sequencing and pattern formation in the embryonic development stages. It is expressed mainly in the central nervous system and developing tissues but also shows functionality in adult tissues. The activity of HoxC6 affects cellular differentiation and proliferation by regulating specific gene expression in these regions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein binds to DNA at specific sequences to activate or repress target gene transcription. This can affect cell fate and organ morphogenesis. HoxC6 associates with other Hox proteins and cofactors to form complexes that enhance or modify its regulatory functions. These interactions with cofactor proteins further strengthen its impact on developmental processes ensuring accurate tissue and organ formation.\u003cbr\u003e\nPathways\u003cbr\u003e\nHoxC6 functions within pivotal developmental pathways such as the Hox gene regulatory network. This network synchronizes with signaling pathways like the Wnt and Notch controlling cell proliferation and differentiation. The collaboration with these pathways allows HoxC6 to manage gene cascades that maintain the correct body patterning. HoxB5 a related protein in the same pathway often interacts or shares similar roles coordinating to maintain orderly tissue patterning.\u003cbr\u003e\nMalfunction or mis-expression of HoxC6 links to certain cancers including leukemia and breast cancer. The protein's deregulation can lead to abnormal cell growth and differentiation. It works alongside proteins like Myc which also plays a central role in cancer to influence oncogenesis. Studies continue to explore HoxC6's involvement in these diseases considering its role in normal cellular development and potential therapeutic targeting.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851892248745,"sku":"ab249014","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab249014","provider":"Iright","version":"1.0","type":"link"}