{"product_id":"abcam-ab249044","title":"Abcam, ab249044, Anti-ADRA2B antibody [EPR9623] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ADRA2B antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9623,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249044 is the carrier-free version of\u003cbr\u003e\nab151727\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nADRA2B also known as alpha-2B adrenergic receptor is a G protein-coupled receptor with an approximate mass of 50 kDa. It is specifically involved in the regulation of neurotransmitter release playing a critical role in the sympathetic nervous system. The receptor is expressed in several tissues including the brain heart and lungs. It has a high affinity for catecholamines and by binding to these ligands ADRA2B modulates various physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe alpha-2B adrenergic receptor is involved in mediating vasoconstriction and neurotransmission. This receptor is part of a larger complex of adrenergic receptors which includes alpha-2A and alpha-2C subtypes. Through its activity ADRA2B influences cardiovascular functions by controlling blood vessel tone and cardiac output. The receptor also plays roles in the central nervous system by affecting neurotransmitter release which impacts stress and arousal responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe alpha-2B adrenergic receptor participates in the adrenergic signaling pathway influencing cardiovascular and nervous system activities. In this pathway it is associated with G protein interactions leading to inhibition of adenylate cyclase and reduction of cAMP levels. ADRA2B also interacts with proteins such as Giα subunits which further disseminate signals involved in the regulation of physiological responses like heart rate and vascular resistance.\u003cbr\u003e\nThe alpha-2B adrenergic receptor has links with cardiovascular diseases and psychiatric disorders. Dysregulation or mutations in ADRA2B may contribute to conditions like hypertension by affecting vasoconstriction and cardiovascular stability. Additionally alterations in receptor function could relate to mood disorders such as depression due to its role in neurotransmitter regulation. ADRA2B interacts with other adrenergic receptors and neurotransmitter systems influencing the pathophysiology of these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851737190569,"sku":"ab249044","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab249044","provider":"Iright","version":"1.0","type":"link"}