{"product_id":"abcam-ab249062","title":"Abcam, ab249062, Anti-MGT4A antibody [EPR10034] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal MGT4A antibody. Carrier free. Suitable for IHC-P, ICC\/IF, WB, IP, Flow Cyt and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10034,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, IP, Flow Cyt, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249062 is the carrier-free version of\u003cbr\u003e\nab151750\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMGT4A also known as Magnesium Transporter 4A is a protein involved in magnesium ion translocation. Weighing approximately 40 kDa this protein functions as an integral membrane protein primarily facilitating the movement of magnesium ions across cellular membranes. MGT4A can be found expressed in various tissues with significant levels observed in the intestinal epithelium. It plays a critical role in maintaining magnesium homeostasis within cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe magnesium transporter MGT4A helps regulate intracellular magnesium levels which are important for numerous cellular functions including enzymatic reactions and signal transduction. MGT4A operates as part of a larger magnesium transport complex that is responsible for ensuring the proper uptake and distribution of magnesium ions within cells. This regulation is essential for maintaining the activity of many magnesium-dependent processes within the body.\u003cbr\u003e\nPathways\u003cbr\u003e\nMagnesium homeostasis is an important function of MGT4A and it participates in cellular metabolism and energy production pathways. MGT4A interacts with proteins involved in the cation transport pathway ensuring balanced magnesium levels which are necessary for ATP production and DNA synthesis. It is also related to the transporter family that includes other cation transport proteins which have roles in similar biological pathways.\u003cbr\u003e\nMutations or malfunctions in MGT4A can lead to conditions such as hypomagnesemia and hypertension. These diseases stem from disrupted magnesium levels affecting cardiovascular and epithelial cell functions. In the context of these conditions MGT4A interacts with other transporter proteins like those involved in calcium and sodium ion transport underlining its significance in ion homeostasis and highlighting its potential as a therapeutic target for related disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851632431273,"sku":"ab249062","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab249062","provider":"Iright","version":"1.0","type":"link"}