{"product_id":"abcam-ab249291","title":"Abcam, ab249291, Anti-CETP antibody [EPR13] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal CETP antibody. Carrier free. Suitable for IP, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249291 is the carrier-free version of\u003cbr\u003e\nab157183\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCETP also known as Cholesteryl Ester Transfer Protein is a plasma glycoprotein with a molecular mass of approximately 74 kDa. It is primarily expressed in the liver and circulates in the bloodstream. CETP mediates the transfer of cholesteryl esters and triglycerides between high-density lipoproteins (HDL) and low-density lipoproteins (LDL) influencing lipid balance in human plasma. This protein is essential for regulating the distribution and composition of HDL and LDL particles impacting lipid homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCETP plays a role in lipid metabolism by facilitating the redistribution of lipids among various lipoprotein particles. CETP does not function as part of a larger molecular complex but actively interacts with lipoproteins in a reversible manner. Its activity affects the levels of HDL cholesterol often referred to as \"good cholesterol\" and contributes to maintaining lipid levels within physiological limits. By modulating the lipid exchanges CETP influences atherosclerosis progression and cardiovascular health.\u003cbr\u003e\nPathways\u003cbr\u003e\nCETP interacts significantly with lipoprotein metabolism and reverse cholesterol transport pathways. It works alongside key proteins such as apolipoprotein A-I and apolipoprotein B which are present in HDL and LDL particles respectively. CETP activity in these pathways modulates the cholesterol efflux capability of HDL affecting lipid clearance from tissues back to the liver. These interactions ensure the maintenance of cholesterol equilibrium and are vital in lipid recycling processes.\u003cbr\u003e\nCETP is closely linked to cardiovascular diseases and atherosclerosis. Elevated CETP activity correlates with low HDL cholesterol levels and higher risk of coronary artery disease. CETP inhibitors have been researched for their potential to increase HDL levels and reduce cardiovascular risk. Furthermore CETP activity influences the pathology of metabolic syndrome where lipid imbalances exacerbate the condition. Proteins related to CETP in these contexts include HDL and LDL which are altered in their distributions by CETP's activity impacting disease progression and management.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851262087337,"sku":"ab249291","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab249291","provider":"Iright","version":"1.0","type":"link"}