{"product_id":"abcam-ab249334","title":"Abcam, ab249334, Anti-DLC-A antibody [EPR11240] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal DLC-A antibody. Carrier free. Suitable for IHC-P, ICC\/IF, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11240,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249334 is the carrier-free version of\u003cbr\u003e\nab157468\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDLC-A also known as Deleted in Liver Cancer-1 or ARHGEF5 is a Rho guanine nucleotide exchange factor with a mass of approximately 205 kDa. This protein plays a role in cellular processes by activating members of the Rho GTPase family which are key regulators of the cytoskeleton. DLC-A is expressed in various tissues including liver kidney and heart suggesting its broad implication in cellular functions across different organ systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDLC-A acts as a guanine nucleotide exchange factor facilitating the exchange of GDP for GTP on Rho family GTPases. This activity leads to the activation of these GTPases promoting cytoskeletal rearrangements and influencing cell shape motility and growth. DLC-A integrates into large protein complexes interacting with various other signaling molecules that modulate its activity in different cellular contexts highlighting its broad involvement in cell dynamics.\u003cbr\u003e\nPathways\u003cbr\u003e\nMany cellular transformations and regulatory systems involve DLC-A. DLC-A participates in the Rho signaling pathway important for actin cytoskeleton dynamics. It also interacts with the MAPK\/ERK pathway which influences cell division and survival. In these pathways DLC-A connects with proteins like RhoA and ERK1\/2 showing its pivotal role in signal transduction and cellular responses to external signals.\u003cbr\u003e\nGenomic alterations and expression changes in DLC-A have links to cancer progression especially in liver cancer. Researchers have found that altered DLC-A expression affects tumor formation and metastasis through its action in cytoskeletal remodeling and cell movement. Furthermore DLC-A relates to cardiovascular disorders due to its significant effects on vascular cell function. In these contexts DLC-A interacts with other proteins like PI3K and Akt which are involved in cell proliferation and survival emphasizing its role in disease etiology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46856358690985,"sku":"ab249334","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab249334","provider":"Iright","version":"1.0","type":"link"}