{"product_id":"abcam-ab249609","title":"Abcam, ab249609, Anti-TPR antibody [EPR8982] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TPR antibody. Carrier free. Suitable for ICC\/IF, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8982,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249609 is the carrier-free version of\u003cbr\u003e\nab170940\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe translocated promoter region protein (TPR) also known commonly as 'horse TPR' consists of approximately 267 kDa. TPR is a nucleoporin protein primarily expressed in the nuclear envelope of eukaryotic cells. It serves as a structural and regulatory component of the nuclear pore complex (NPC) playing a critical role in nucleocytoplasmic transport. A structural scaffold TPR facilitates the organization and entrance of nuclear transport receptors and cargo molecules through the NPC impacting the efficient movement of proteins and RNA across the nuclear membrane.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTPR interacts with other nucleoporins within the NPC to ensure proper nuclear function. TPR is integral in maintaining the spatial organization and transport selectivity within the nucleoplasm-cytoplasm interface by forming an interaction network with other proteins like NUP98 and NUP153. TPR functions as part of the NPC assembly contributing to essential cellular processes like gene expression regulation and DNA repair by participating in chromatin organization.\u003cbr\u003e\nPathways\u003cbr\u003e\nTPR integrates into the nuclear transport pathway and it also plays a role in the MAPK signaling pathway. Within the nuclear transport pathway TPR facilitates the proper translocation of molecules necessary for downstream cellular functions. In the MAPK signaling pathway it synchronizes with other proteins like ERK to control processes such as proliferation and differentiation. TPR's interaction with these pathways positions it as an important player in cellular communication and response.\u003cbr\u003e\nTPR has connections to cancer and neurodegenerative diseases. In various cancers abnormal TPR function impacts cell growth and proliferation by altering nuclear transport dynamics. Additionally it associates with Alzheimer's disease through its interactions with tau protein affecting neuronal function. These connections make TPR a significant target for understanding disease mechanisms and developing therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851839262889,"sku":"ab249609","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab249609","provider":"Iright","version":"1.0","type":"link"}