{"product_id":"abcam-ab249680","title":"Abcam, ab249680, Anti-CACNA1F antibody [EPR11822] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal CACNA1F antibody. Carrier free. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11822,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249680 is the carrier-free version of\u003cbr\u003e\nab171968\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe CACNA1F gene encodes the alpha-1F subunit of a voltage-dependent L-type calcium channel. This protein also known as Cav1.4 has a mass of approximately 230 kDa. It facilitates the influx of calcium ions into the cells in response to changes in electric potential across the cell membrane. The protein is expressed mainly in the retina where it plays an important role in the function of photoreceptor cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe CACNA1F protein influences neurotransmitter release by regulating calcium entry which is essential for visual processing. It functions as a part of a larger voltage-gated calcium channel complex where its role is to fine-tune calcium signals. This precise control is necessary for the proper response to light stimuli in the eye allowing effective signal transmission to the visual pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe CACNA1F protein integrates into the calcium signaling pathway important for neuronal communication and sensory processes. It is also linked to the phototransduction cascade in the retina. Within these pathways CACNA1F interacts with related proteins like beta subunits that modulate the activity of the L-type calcium channels impacting overall visual function.\u003cbr\u003e\nMutations in the CACNA1F gene are associated with X-linked congenital stationary night blindness and other retinal disorders. These conditions can lead to an impaired vision due to the disrupted calcium flow in photoreceptors. Additionally CACNA1F shows a relationship with other calcium channel proteins like CACNA1S potentially influencing disorder phenotypes through altered ionic homeostasis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860567740585,"sku":"ab249680","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab249680","provider":"Iright","version":"1.0","type":"link"}