{"product_id":"abcam-ab249690","title":"Abcam, ab249690, Anti-TIMMDC1\/C3orf1 antibody [EPR11807] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TIMMDC1\/C3orf1 antibody. Carrier free. Suitable for ICC\/IF, IP, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11807,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249690 is the carrier-free version of\u003cbr\u003e\nab171978\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTIMMDC1 also known as C3orf1 is a mitochondrial protein with a mass of approximately 34 kDa. It plays a mechanical role in the assembly of mitochondrial respiratory chain complex I. It becomes integrated into the inner mitochondrial membrane where it acts as an important assembly factor. TIMMDC1 is expressed ubiquitously across various human tissues with relatively higher levels in tissues with high energy demands like the heart and skeletal muscle.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTIMMDC1 is essential in maintaining cellular energy metabolism. It is a component of the mitochondrial complex I assembly pathway critical for the formation and stabilization of the entire complex I. Complex I is responsible for the initial steps of the electron transport chain important for ATP production via oxidative phosphorylation. TIMMDC1 interacts with other complex I assembly factors contributing to the efficient generation of ATP within mitochondria.\u003cbr\u003e\nPathways\u003cbr\u003e\nTIMMDC1 has a significant impact on the oxidative phosphorylation pathway and is a pivotal part of the mitochondrial respiratory chain. Its activity influences cellular respiration by assisting the functional integrity of complex I which interacts closely with other oxidative phosphorylation participants such as NADH dehydrogenase (ubiquinone) and cytochrome c oxidase. TIMMDC1 plays its role alongside these proteins facilitating the production of energy that cells require for various metabolic processes.\u003cbr\u003e\nDefects in TIMMDC1 have been linked to mitochondrial complex I deficiency a condition that can result in a spectrum of disorders such as Leigh syndrome and other encephalomyopathies. This protein's malfunction can disrupt normal energy production leading to energy deficits in cells particularly in the nervous system and muscles. Additionally disruptions in the TIMMDC1 protein interaction with other mitochondrial proteins can exacerbate disease phenotypes such as with NDUFAF3 another mitochondrial assembly factor associated with complex I deficiency.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851871637673,"sku":"ab249690","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab249690","provider":"Iright","version":"1.0","type":"link"}