{"product_id":"abcam-ab249753","title":"Abcam, ab249753, Anti-LSM12 antibody [EPR12282-87] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal LSM12 antibody. Carrier free. Suitable for IHC-P, ICC\/IF, IP, WB and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12282-87,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IP, ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249753 is the carrier-free version of\u003cbr\u003e\nab173292\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLSM12 also known as LSM12 homolog is a protein with a molecular weight of approximately 16 kDa. This protein is part of the Sm-like family known for their role in RNA processing. LSM12 is ubiquitously expressed in various tissues but shows higher presence in brain tissue indicating its potential importance in neurological functions. Its expression patterns suggest that LSM12 may have diverse roles across different cellular contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein is involved in cellular processes associated with mRNA decay and stability. LSM12 is a component of the LSM protein complex which plays an important role in RNA metabolism. The complex ensures accurate degradation and processing of mRNAn important steps required for maintaining cellular RNA homeostasis. Within the complex LSM12 interacts with other LSM proteins to promote efficient RNA handling and control.\u003cbr\u003e\nPathways\u003cbr\u003e\nLSM12 is associated with RNA processing pathways including the nonsense-mediated decay (NMD) pathway. This pathway ensures the elimination of faulty mRNA transcripts which if left unchecked can disrupt cellular functions. In these pathways LSM12 may interact with UPF1 a well-known protein involved in NMD aiding in identifying and degrading erroneous mRNA molecules. This suggests that LSM12 supports the maintenance of genomic integrity through RNA surveillance mechanisms.\u003cbr\u003e\nResearchers link LSM12 to neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. These connections highlight the significance of proper RNA metabolism in neuronal function. LSM12's interaction with other RNA processing proteins such as TDP-43 in ALS suggests a potential disruption of RNA stability as a contributing factor in these diseases. The study of LSM12 offers valuable insights into therapeutic targets for neurological conditions related to mRNA dysfunction.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860449710249,"sku":"ab249753","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab249753","provider":"Iright","version":"1.0","type":"link"}