{"product_id":"abcam-ab249795","title":"Abcam, ab249795, Anti-MYO19 antibody [EPR12551-13] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal MYO19 antibody. Carrier free. Suitable for ICC\/IF, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12551-13,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249795 is the carrier-free version of\u003cbr\u003e\nab174286\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe MYO19 protein also known as Myosin XIX functions as an ATP-dependent motor protein. It possesses a molecular mass of approximately 119 kDa and is part of the myosin superfamily. This protein is known for its role in cellular processes requiring motility including vesicle and organelle transport. MYO19 is widely expressed in tissues with notable expression in the brain and skeletal muscles suggesting its importance in those regions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMYO19 contributes to mitochondrial dynamics by participating in mitochondrial motility and positioning within cells. While MYO19 is not part of a larger protein complex it interacts with the mitochondrial outer membrane and aids in tethering mitochondria to the cytoskeleton. This interaction is essential for maintaining proper cellular function specifically in energy-demanding tissues.\u003cbr\u003e\nPathways\u003cbr\u003e\nMYO19 interacts with cellular transport mechanisms notably involving the actin cytoskeleton pathway. The protein facilitates mitochondrial movement along actin filaments. It shares pathways with other myosin family members such as MYO5 which are involved in intracellular transport. Additionally MYO19's role in actin-related pathways underlines its involvement in regulating cellular energy distribution and homeostasis.\u003cbr\u003e\nMYO19 has potential links with neurodegenerative diseases and muscular disorders. Disruption in MYO19 function may lead to impaired mitochondrial distribution contributing to the pathology of conditions like amyotrophic lateral sclerosis (ALS). Additionally the protein shows possible connections with neurofilament-associated proteins suggesting a role in neural health. Such associations highlight the significance of MYO19 in understanding disease mechanisms and designing therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851838541993,"sku":"ab249795","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab249795","provider":"Iright","version":"1.0","type":"link"}