{"product_id":"abcam-ab249806","title":"Abcam, ab249806, Anti-TRNP1 antibody [EPR11958] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TRNP1 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11958,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249806 is the carrier-free version of\u003cbr\u003e\nab174303\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRNP1 also known as Ternary Complex Factor Small Nuclear Ribonucleic Protein 1 is a protein involved in DNA-binding activities. It has a mass of approximately 25 kDa. TRNP1 is expressed in various tissues most predominantly in the brain and neural tissues. It acts as a transcription factor binding to specific DNA sequences and influences the expression of genes involved in brain development and neural cell proliferation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTRNP1 regulates the proliferation and differentiation of neural progenitor cells. This protein does not appear to form part of a larger protein complex but it directly affects cellular processes that shape the growth and arrangement of the cerebral cortex during embryonic development. Its expression levels can control the cellular architecture influencing neural tube closure and cortical folding.\u003cbr\u003e\nPathways\u003cbr\u003e\nTRNP1 plays a role in neural development pathways and interacts significantly with the Wnt signaling pathway. It regulates genes that are important for maintaining the balance between neural progenitor cell proliferation and differentiation. In this pathway TRNP1 may have an interaction with proteins like Wnt and β-catenin that control cellular growth decisions affecting brain size and function eventually.\u003cbr\u003e\nAlterations in TRNP1 levels or function relate to disorders such as microcephaly and possibly certain neurodevelopmental dysplasias. It has been suggested that imbalances in TRNP1 activity can disrupt cortical development leading to abnormal brain development. While comprehensive studies are ongoing TRNP1 potentially interacts with proteins associated with these disorders marking its importance in neural developmental research.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851951493289,"sku":"ab249806","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab249806","provider":"Iright","version":"1.0","type":"link"}