{"product_id":"abcam-ab249830","title":"Abcam, ab249830, Anti-AdSS 2 antibody [EPR12331-52] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal AdSS 2 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12331-52,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249830 is the carrier-free version of\u003cbr\u003e\nab174842\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAdSS 2 also known as Adenylate Succinate Synthase 2 is an enzyme that functions in the cellular ATP generation process. It catalyzes an important step in the purine nucleotide cycle specifically the conversion of inosine monophosphate (IMP) to adenylosuccinate. This enzyme has an approximate molecular weight of 55 kDa. AdSS 2 is widely expressed in tissues with high energy demands such as liver muscle and brain where it plays a major role in maintaining cellular energy balance.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAdSS 2 is important for the synthesis of AMP from IMP acting as a part of the purine biosynthesis pathway. It does not work alone; it associates with other enzymes involved in the nucleotide metabolism complex ensuring efficiency of ATP production. This activity supports various cellular functions that require rapid energy turnover reflecting its necessity in tissues with intense metabolic activity.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis enzyme integrates into the broader purine metabolism and energy homeostasis pathways. It connects with the enzyme fumarase in a pathway that regulates the TCA cycle's connection to nucleotide metabolism. Furthermore its interaction with proteins like adenylosuccinate lyase shows its involvement in the cascading steps of purine synthesis helping maintain a balance between energy supply and demand.\u003cbr\u003e\nAdSS 2 has relevant implications in metabolic conditions like gout and certain types of myopathies. Mutations in this enzyme can disrupt purine metabolism leading to excessive accumulation of uric acid a hallmark of gout. Similarly impaired AdSS 2 function links to muscle disorders where energy metabolism is compromised. Proteins such as adenylosuccinate lyase and fumarase may be co-involved in these metabolic disorders highlighting the interconnected nature of metabolic function and disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851948019881,"sku":"ab249830","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab249830","provider":"Iright","version":"1.0","type":"link"}