{"product_id":"abcam-ab250040","title":"Abcam, ab250040, Anti-NUB1 antibody [EPR10717] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal NUB1 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10717,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250040 is the carrier-free version of\u003cbr\u003e\nab178414\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNUB1 also known as NEDD8 ultimate buster-1 functions as a negative regulator of NEDD8 conjugation. This protein weighs around 65 kDa. Researchers find NUB1 to be widely expressed in the human body with higher expression levels observed in organs like the heart and brain. NUB1 interacts mainly with ubiquitin-like proteins including NEDD8 and facilitates their degradation by the proteasome reducing NEDD8's presence in cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNUB1 influences protein homeostasis and signal transduction. It associates with the proteasome to target and eliminate neddylated proteins contributing to the regulation of protein turnover. NUB1 also forms part of a complex that affects the cellular levels of specific proteins through the ubiquitin-proteasome system. This action helps maintain cellular protein balance and impacts various cellular functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe ubiquitin-proteasome system revolves around NUB1 as it regulates neddylation and ubiquitination processes. NUB1 connects to the neddylation pathway which includes proteins like NEDD8 and UBA3 influencing protein activities and degradation. Through its association with ubiquitination it regulates the stability and function of key cellular proteins ensuring proper cell function and preventing harmful protein accumulation.\u003cbr\u003e\nNUB1 shows a connection with neurodegenerative diseases and certain cancers. In neurodegenerative conditions like Alzheimer's disease NUB1's regulatory function impacts protein aggregates' formation potentially influencing disease progression. NUB1 also interacts with proteins linked to cancer pathways such as ubiquitin implicating it in the development of certain malignancies. Adequate function and regulation of NUB1 may therefore play a role in mitigating these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851903979689,"sku":"ab250040","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab250040","provider":"Iright","version":"1.0","type":"link"}