{"product_id":"abcam-ab250146","title":"Abcam, ab250146, Anti-PTPRR\/PCPTP1 antibody [EPR13188] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PCPTP1\/PTPRQ antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13188,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250146 is the carrier-free version of\u003cbr\u003e\nab180134\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein tyrosine phosphatase receptor type R (PTPRR) also known as PCPTP1 acts as a signaling molecule that regulates phosphorylation states in various cellular processes. The molecular mass of PTPRR is approximately 72 kDa. PTPRR predominantly expresses in the nervous system especially in the brain and cerebellum where it influences neuronal signaling pathways. Its role in the modulation of kinase activity highlights its importance in cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPTPRR regulates the activity of mitogen-activated protein kinases (MAPKs) critical elements of intracellular signaling. PTPRR functions as part of multiprotein complexes involving MAPKs affecting their dephosphorylation and inactivation. This modulation influences several cellular responses such as cell growth differentiation and development asserting a significant role in neurophysiological processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe PTPRR protein plays a role in the MAP kinase signaling pathway and the JNK pathway. By interacting with MAPKs like ERK it helps modulate the transmission of extracellular signals to cellular responses ensuring the appropriate cellular outcome. PTPRR through these pathways relates with other tyrosine phosphatases and interacts with adaptor proteins contributing to signal transduction fidelity and complexity.\u003cbr\u003e\nAlterations in PTPRR function connect to neurological and psychiatric conditions. Dysregulation of PTPRR can lead to abnormal brain function with associations to disorders like schizophrenia and certain neurodegenerative diseases. Through these disease contexts PTPRR links with other phosphatases such as DUSP6 and MAP kinases highlighting its role in maintaining neuronal health and its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852384293033,"sku":"ab250146","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab250146","provider":"Iright","version":"1.0","type":"link"}