{"product_id":"abcam-ab250155","title":"Abcam, ab250155, Anti-Orai2 antibody [EPR10043(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ORAI2 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10043(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250155 is the carrier-free version of\u003cbr\u003e\nab180146\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOrai2 also known as Orai calcium-release-activated calcium modulator 2 is a protein that functions as a calcium channel subunit. It plays an important role in regulating calcium influx into cells. Orai2 is a transmembrane protein expressed in various tissues including the brain and muscle. The protein has a mass of approximately 33 kDa. Orai2 forms part of a channel complex important for controlling the amount of calcium that enters cells in response to signals.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOrai2 modulates calcium homeostasis by forming a complex with other proteins in the Orai family such as Orai1 and Orai3. Calcium ions are essential for numerous cellular processes including muscle contraction neurotransmitter release and gene expression. Orai2 helps to fine-tune the calcium signaling pathways that decide these processes. By collaborating with other calcium channels and regulatory proteins Orai2 adjusts the cellular calcium influx that tackles specific cellular needs.\u003cbr\u003e\nPathways\u003cbr\u003e\nCalcium release-activated calcium (CRAC) channels represent an important biological route in which Orai2 participates. The CRAC channel mechanism involves the interaction with stromal interaction molecule 1 (STIM1) a protein that senses calcium depletion in the endoplasmic reticulum. Orai2 when associated with STIM1 conducts calcium ions into the cytosol maintaining intracellular calcium levels required for various cellular responses. Additionally Orai2 interacts within pathways that involve Orai1 and STIM-like protein 1 (STIM2) highlighting its role in regulating cellular calcium mechanisms.\u003cbr\u003e\nOrai2 relates to immune system dysfunctions and neurological conditions. Abnormal alterations in Orai2 function can contribute to immunodeficiency as calcium entry through Orai channels influences immune cell activation and response. Additionally alteration in Orai2 function can affect neuronal signaling having potential links to conditions like epilepsy. Orai2's function in these disorders may involve interactions with related proteins such as Orai1 and STIM1 which also play a part in these pathways. Understanding Orai2's role offers potential avenues for treating related conditions by targeting calcium entry mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851910336681,"sku":"ab250155","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab250155","provider":"Iright","version":"1.0","type":"link"}