{"product_id":"abcam-ab250186","title":"Abcam, ab250186, Anti-MLF2 antibody [EPR10245(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal MLF2 antibody. Carrier free. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10245(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250186 is the carrier-free version of\u003cbr\u003e\nab180184\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMLF2 also known as Myeloid Leukemia Factor 2 is a protein with an approximate mass of 35 kDa. It shows expression mainly in the nucleus and cytoplasm of cells. MLF2 takes part in the regulation of various cellular processes especially those involving cell growth and differentiation. Understanding its activity and expression pattern can help in dissecting its role in cellular function and disease.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMLF2 contributes to cells' response to stress making it significant in maintaining cellular homeostasis. MLF2 can interact with other proteins to form complexes that regulate transcriptional processes. This regulation is important for normal cellular function and indicates that MLF2 has an influence on gene expression modulation impacting how the cell responds to different stimuli.\u003cbr\u003e\nPathways\u003cbr\u003e\nMLF2 engages in the JAK\/STAT signaling pathway which is important in processes like cell proliferation differentiation and apoptosis. It also interacts with the NF-kB signaling pathway important for immune response and inflammation regulation. Through these pathways MLF2 shares connections with proteins such as STAT3 and NF-kB indicating its integration into a network that maintains cellular activity and integrity.\u003cbr\u003e\nMLF2 associates with cancer and myelodysplastic syndromes. Its altered expression or dysfunction can contribute to tumorigenesis due to its role in cell proliferation and differentiation pathways. In these disease contexts MLF2's interaction with proteins like JAK2 becomes critical as disruptions in these interactions may exacerbate disease progression. Understanding these connections helps in considering MLF2 as a potential therapeutic target in disease treatment strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851755311273,"sku":"ab250186","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab250186","provider":"Iright","version":"1.0","type":"link"}