{"product_id":"abcam-ab250242","title":"Abcam, ab250242, Anti-PGBD1 antibody [EPR13883] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PGBD1 antibody. Carrier free. Suitable for ICC\/IF, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13883,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250242 is the carrier-free version of\u003cbr\u003e\nab180598\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPGBD1 also known as PiggyBac Transposable Element-Derived 1 is a DNA transposase-like protein. The human PGBD1 protein has a molecular mass of approximately 98 kDa. It is a member of the piggyBac family of transposases and is highly expressed in the brain and various other tissues. PGBD1 has a sequence that shows homology to known active transposases but lacks the catalytic triad of DDD signature suggesting a more complex role beyond simple transposition mechanics.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe gene encoding PGBD1 is involved in processes related to genomic stability and chromatin remodeling although it does not form part of a known multiprotein complex. This protein plays roles in gene expression regulation and might affect chromatin through non-transposase activity. It is hypothesized that PGBD1 might bind to specific DNA sequences impacting chromatin state and gene activity. Its exact biological function remains under investigation but the regulation of neural-related genes implicates a role in neural tissue development and maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nPGBD1 is involved in the regulation of chromatin structure and gene expression pathways. Its interactions influence pathways like the DNA damage response contributing to cellular reactions to stress at the genetic level. The protein may not operate alone but has functional associations with chromatin remodelers such as Polycomb group proteins which are important in managing gene expression patterns during development and differentiation.\u003cbr\u003e\nDysregulation or mutations of PGBD1 suggest potential links with neurodevelopmental disorders and cancer. Altered expression patterns have been noted in neuroblastoma implying interactions with proteins like MYCN an important oncogene. PGBD1's effect on chromatin dynamics could influence the genomic environment leading to disease-associated changes in gene expression. Further research seeks to clarify these connections and determine potential therapeutic targets or biomarkers.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851840639145,"sku":"ab250242","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab250242","provider":"Iright","version":"1.0","type":"link"}