{"product_id":"abcam-ab250411","title":"Abcam, ab250411, Anti-EIF2B1 antibody [EPR13894(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal EIF2B1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13894(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250411 is the carrier-free version of\u003cbr\u003e\nab181186\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEIF2B1 also known as eukaryotic translation initiation factor 2B subunit alpha functions mechanically as a regulatory subunit in the eIF2B complex. This protein has a mass of approximately 38 kDa. EIF2B1 is expressed in various tissues throughout the body including the brain heart liver and muscle. It plays a critical role in protein synthesis by regulating the exchange of GDP for GTP on the eIF2 protein which is essential for initiating translation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEIF2B1 regulates protein synthesis by modulating the activity of the eIF2B complex which is a guanine nucleotide exchange factor. This complex comprises five subunits and EIF2B1 is integral for its function. Through regulation of eIF2 EIF2B1 indirectly controls the rate of translation initiation affecting cell growth and stress response mechanisms. In neurons EIF2B1’s activity influences neuronal development and maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nEIF2B1 functions prominently in both the unfolded protein response and integrated stress response pathways. These pathways respond to cellular stress by altering translation rates and are essential for maintaining protein homeostasis. EIF2B1 interacts primarily through these pathways with other proteins such as eIF2 and ATF4 which is a transcription factor activated during stress responses.\u003cbr\u003e\nEIF2B1 plays a significant role in disorders like Vanishing White Matter (VWM) disease. Mutations in the EIF2B1 gene can lead to VWM a genetic condition affecting the central nervous system and presenting symptoms such as ataxia and neurological deterioration. Additionally disruption of EIF2B1 function relates to stress-related disorders due to its role in stress response pathways. Through these pathways EIF2B1 associates with proteins like eIF2 which can also affect susceptibility to stress disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848566263977,"sku":"ab250411","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab250411","provider":"Iright","version":"1.0","type":"link"}