{"product_id":"abcam-ab250422","title":"Abcam, ab250422, Anti-RPL14 antibody [EPR12301] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal RPL14 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12301,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250422 is the carrier-free version of\u003cbr\u003e\nab181200\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe RPL14 protein also known as ribosomal protein L14 plays an important role in the ribosomal 60S subunit which is essential for protein synthesis. This protein has a molecular weight of around 15 kDa and is primarily expressed in the cytoplasm. As a component of the ribosome RPL14 contributes to the structure and stability of ribosomal RNA facilitating the translation process.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRibosomal protein L14 integrates into the large ribosomal subunit participating in the assembly of the ribosome complex. RPL14 binds to 28S rRNA and contributes to the ribosome’s ability to accurately synthesize proteins. It works alongside other ribosomal proteins and RNA to ensure efficient translation of messenger RNA (mRNA) into proteins impacting cell growth and proliferation.\u003cbr\u003e\nPathways\u003cbr\u003e\nRPL14 has significant involvement in the translation pathway critical for genetic expression and protein synthesis. It interacts with other ribosomal proteins within the translation machinery such as RPL5 and RPL11 to facilitate the binding of the aminoacyl-tRNA to the ribosome. In the context of the mTOR signaling pathway RPL14 potentially influences cell growth and metabolism by regulating protein synthesis rates.\u003cbr\u003e\nThe dysfunction of ribosomal protein L14 associates with certain ribosomopathies which are disorders caused by ribosomal dysfunction. Mutations or altered expression of RPL14 can also relate to cancer where deregulated protein synthesis contributes to uncontrolled cell proliferation. The interaction of RPL14 with other ribosomal proteins like RPL11 suggests its involvement in the maintenance of genomic integrity further linking it to disease states characterized by disrupted cellular homeostasis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851824910505,"sku":"ab250422","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab250422","provider":"Iright","version":"1.0","type":"link"}