{"product_id":"abcam-ab250643","title":"Abcam, ab250643, Anti-PGAM2 antibody [EPR15193(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PGAM2 antibody. Carrier free. Suitable for IHC-P, IP, WB, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15193(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-P, Flow Cyt (Intra), IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250643 is the carrier-free version of\u003cbr\u003e\nab183027\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb\u003cbr\u003e\npatents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPGAM2 or phosphoglycerate mutase 2 is an enzyme and plays an important role in glycolysis. This enzyme catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate. PGAM2 is known for its molecular weight of approximately 29 kDa. It expresses in skeletal muscle tissue predominantly allowing it to help meet the energy demands during muscle contraction. The activity of PGAM2 is essential in tissues that require high energy supply.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme PGAM2 is important in energy metabolism within the cells. It participates in the glycolytic pathway which leads to ATP production necessary for cell survival and functioning. PGAM2 acts as part of the glycolytic enzyme complex. By enabling the conversion of intermediates PGAM2 facilitates the continuous flow of the glycolytic cascade necessary for efficient energy extraction from glucose.\u003cbr\u003e\nPathways\u003cbr\u003e\nPGAM2's function is central in glycolysis and gluconeogenesis. These pathways are essential for energy production and glucose homeostasis respectively. It collaborates with proteins such as enolase the enzyme responsible for converting 2-phosphoglycerate to phosphoenolpyruvate further down the glycolytic pathway. These interactions support the efficient production of ATP and gluconeogenic capabilities of the liver and kidney where energy conservation and storage are fundamental.\u003cbr\u003e\nPGAM2 deficiency has connections to metabolic and muscular conditions. One of the diseases associated with PGAM2 is glycogen storage disease type X also known as muscle phosphoglycerate mutase deficiency. It affects muscle function by disrupting glycolysis. Additionally aberrations in PGAM2 activity can associate with metabolic dysfunctions often connected to proteins such as lactate dehydrogenase which gatekeeps the final steps of anaerobic glycolysis. Studying PGAM2 deeply and its links to these diseases provides insights for potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844243574953,"sku":"ab250643","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab250643","provider":"Iright","version":"1.0","type":"link"}