{"product_id":"abcam-ab250764","title":"Abcam, ab250764, Anti-SNAP-beta antibody [EPR15046(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal SNAP-beta antibody. Carrier free. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15046(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250764 is the carrier-free version of\u003cbr\u003e\nab184563\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSNAP-beta also known as SNAP-23 is part of the SNARE family consisting of about 23 kDa proteins. This protein plays a role in vesicular transport processes working in the docking and fusion of vesicles with membranes. Expressed broadly in mammalian tissues SNAP-beta shows higher levels in brain and adipose tissue indicating its involvement in vital cellular functions across various organs.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSNAP-beta contributes to the regulation of membrane trafficking essential for processes such as neurotransmitter release and insulin-mediated glucose uptake. It acts as a member of the SNARE complex alongside syntaxin and VAMP proteins facilitating membrane fusion within cells. This functional integration within a complex highlights its significance in efficient intracellular communication.\u003cbr\u003e\nPathways\u003cbr\u003e\nVesicular transport and exocytosis highlight the overlapping roles of SNAP-beta within the cell. SNAP-beta engages in these pathways by interacting with proteins like syntaxin 4 and synaptobrevin. This linkage ensures precise membrane fusion events necessary for effective cellular responses and functions.\u003cbr\u003e\nSNAP-beta has associations with type 2 diabetes and neurological disorders. Altered SNAP-beta function can cause disruptions in insulin signaling and neurotransmitter release contributing to these conditions. It often interacts with proteins like GLUT4 affecting glucose metabolism and synaptic transmission underlining its involvement in related pathophysiological states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851946381481,"sku":"ab250764","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab250764","provider":"Iright","version":"1.0","type":"link"}