{"product_id":"abcam-ab250765","title":"Abcam, ab250765, Anti-FPGS antibody [EPR11064] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal FPGS antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11064,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250765 is the carrier-free version of\u003cbr\u003e\nab184564\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFolate polyglutamate synthase (FPGS) also known as folylpolyglutamate synthase plays an important role in the metabolic processing of folates. This enzyme catalyzes the addition of glutamate residues to folate and its derivatives. The molecular mass of FPGS is around 60 kDa. Researchers have identified its expression in various tissues with notable presence in liver bone marrow and placenta as well as in certain cancer cell lines.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFPGS modifies folates converting them into polyglutamated forms that remain inside the cells. Its role in folate metabolism makes it essential for synthesizing nucleotides and some amino acids. FPGS does not function in isolation; it interacts with substrates in a series of metabolic complexes. Through its activity FPGS impacts DNA synthesis and repair which are critical for cell proliferation and survival.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of FPGS integrates into the folate metabolism and one-carbon metabolic pathways. FPGS contributes to the regulation of folate homeostasis and is synchronous with proteins like dihydrofolate reductase (DHFR) that are important in these pathways. FPGS's activity ensures the maintenance of tetrahydrofolate derivatives necessary for thymidylate and purine synthesis.\u003cbr\u003e\nAlterations in FPGS activity correlate with the development of certain cancers and hematological disorders. Impaired FPGS function can lead to reduced cellular folate retention affecting nucleotide biosynthesis and increasing susceptibility to cancer. In leukemia for instance FPGS activity impacts therapeutic efficacy as it influences the cytotoxic effects of antifolate drugs. Its interaction with methotrexate an antifolate provides an essential mechanism of resistance in cancer treatment.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851897458857,"sku":"ab250765","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab250765","provider":"Iright","version":"1.0","type":"link"}