{"product_id":"abcam-ab250957","title":"Abcam, ab250957, Anti-POC5 antibody [EPR14000-76] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal POC5 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14000-76,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250957 is the carrier-free version of\u003cbr\u003e\nab188330\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPOC5 also known as Proteome of Centriole 5 is a protein encoded by the POC5 gene. The POC5 protein has a molecular mass of about 63 kDa. It is expressed in various tissues with high expression levels noted in the testis and brain. POC5 localizes to the centrioles which are key structures within the centrosome involved in the formation of cilia and flagella essential for cellular movement and organization.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPOC5 contributes to the maintenance and function of centrioles. It forms part of a complex that stabilizes the structure of centrioles ensuring correct centrosome duplication and cycle progression. By maintaining centriole integrity POC5 supports proper cell division and ensures that chromosomal segregation proceeds without errors during mitosis preserving genomic stability.\u003cbr\u003e\nPathways\u003cbr\u003e\nPOC5 integrates into the centrosome duplication pathway and the regulation of the cell cycle. It interacts with other proteins including CEP63 and PLK4 to ensure robust centriole duplication and prevent errors during cell cycle phases. POC5 therefore has an essential role in centrosome-related pathways which govern critical aspects of cell division and replication.\u003cbr\u003e\nPOC5 has been linked to ciliopathies and certain cancers like retinal degeneration and colorectal cancer. In ciliopathies impaired POC5 function disrupts the normal formation and stability of cilia causing defects that can lead to disease. Connections with proteins such as CEP290 in retinal degeneration highlight POC5's involvement in maintaining ciliary function. Increased or altered expression of POC5 in cancer has been observed suggesting its potential role as an oncogenic factor through disrupting normal centrosome function and chromosomal integrity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46856031994025,"sku":"ab250957","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab250957","provider":"Iright","version":"1.0","type":"link"}