{"product_id":"abcam-ab251155","title":"Abcam, ab251155, Anti-ART3 antibody [EPR7220(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ART3 antibody. Carrier free. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7220(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251155 is the carrier-free version of\u003cbr\u003e\nab192870\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nART3 also known as ADP-ribosyltransferase 3 is an enzyme with a molecular mass of approximately 41 kDa. It belongs to the family of ARTs (ADP-ribosyltransferases) which facilitate the transfer of ADP-ribose from NAD+ to target proteins modifying their function. ART3 is mainly expressed on the surface of cells with higher expression observed in testicular tissues. Its distribution suggests a specialized role in certain physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nART3 modifies protein functions by adding ADP-ribose groups a process important for cellular signaling and protein interactions. While it is not as deeply investigated as other ART family members ART3 still plays significant roles in certain biological contexts. It operates independently rather than being part of a larger complex. Current research explores its involvement in sperm maturation and other reproductive functions especially due to its elevated expression in testicular tissue.\u003cbr\u003e\nPathways\u003cbr\u003e\nART3's actions integrate into the wider cellular signaling network influenced by ADP-ribosylation. This modification impacts pathways such as cell communication and possibly apoptosis although detailed mapping in these contexts remains developing. ART3 shares mechanistic similarities with proteins such as ART1 and ART5 which also perform ADP-ribosylation and align with changes in protein activity and signaling dynamics.\u003cbr\u003e\nART3 has potential implications in reproductive health and certain cancers. Altered ART3 expression or function may link to testes-related disorders or contribute to cellular oncogenesis. It connects with other proteins like ART1 whose dysregulation has been studied in various cancers. Understanding ART3's contributions could aid in developing targeted treatments or diagnostics related to its roles in these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851766190249,"sku":"ab251155","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab251155","provider":"Iright","version":"1.0","type":"link"}