{"product_id":"abcam-ab251811","title":"Abcam, ab251811, Anti-BYSL antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal BYSL antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BYSL aa 350 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human BYSL aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q13895\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe biological target BYSL also known as Bystin plays an important role in cell division and growth by participating in ribosomal RNA (rRNA) processing. BYSL has a molecular mass of about 58 kDa. Expression of BYSL occurs mainly in dividing tissues such as the testis and tumor cells where cell proliferation is high. The protein's function involves interaction with other ribonucleoproteins to facilitate the maturation of pre-ribosomal particles.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nBYSL is essential for the assembly of the 90S preribosome a precursor complex pivotal to eukaryotic ribosome biogenesis. It acts alongside other nucleolar proteins to support the assembly and processing of the 18S rRNA necessary for the small ribosomal subunit. Without proper function of BYSL cells experience defects in ribosomal assembly affecting overall protein synthesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nBYSL functions integrally in the ribosome biogenesis pathway a central component of cellular growth and proliferation. It works closely with proteins like NOP58 and UTP18 forming part of the U3 ribonucleoprotein complex essential for early pre-rRNA processing. Another significant pathway is the nucleolar processing of Pre-47S rRNA where BYSL directs ribosome maturation processes ensuring efficient synthesis and cell growth.\u003cbr\u003e\nAbnormalities in BYSL function associate with various cancers emphasizing its connections to uncontrolled cell proliferation. Overexpression or dysfunction of BYSL correlates with tumorigenic processes linking it to proteins such as C-MYC and p53 which also play roles in cancer development. BYSL also relates to the disorder of ribosomopathy where impaired ribosome biogenesis leads to pathological conditions suggesting disruptions that affect overall cellular homeostasis and growth dynamics.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854097141929,"sku":"ab251811","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab251811","provider":"Iright","version":"1.0","type":"link"}