{"product_id":"abcam-ab251923","title":"Abcam, ab251923, Anti-RBM4 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal RBM4 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RBM4 aa 300 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human RBM4 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BWF3\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRNA Binding Motif Protein 4 (RBM4) also known as LARK1 is a RNA-binding protein with a molecular mass of approximately 37 kDa. This protein plays a role in post-transcriptional regulation by binding to RNA and influencing alternative splicing. RBM4 mainly expresses in the cytoplasm of various tissues including muscle and neuronal tissues and is involved in the regulation of mRNA synthesis and turnover. Its function relies on the presence of RNA recognition motifs that facilitate its binding to RNA targets.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRNA Binding Motif Protein 4 impacts cellular processes through its ability to modulate alternative splicing and mRNA translation. It has been shown to form complexes with other RNA-binding proteins and splicing factors enhancing its regulatory capabilities. Through these interactions RBM4 can influence the expression of a wide array of genes involved in cellular development and differentiation adapting protein synthesis to meet cellular and environmental cues.\u003cbr\u003e\nPathways\u003cbr\u003e\nRBM4's function contributes significantly to the regulation of insulin signaling and muscle differentiation pathways. By interacting with other proteins such as SRSF1 and SRPK1 RBM4 aids in modulating the gene splicing required for effective insulin response and muscle cell formation. These interactions ensure that the pathways remain responsive to internal cellular signals and external metabolic demands coordinating essential physiological processes.\u003cbr\u003e\nRNA Binding Motif Protein 4 has been linked to the development of metabolic disorders and certain types of cancer. Aberrant expression or mutations in RBM4 can disrupt normal insulin signaling which may result in type 2 diabetes. In cancer its altered activity can affect cell cycle regulation and apoptosis through connections with other proteins like p53 contributing to tumorigenesis and cancer progression. Understanding the role of RBM4 in these conditions highlights its therapeutic potential as a target for intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854183944361,"sku":"ab251923","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab251923","provider":"Iright","version":"1.0","type":"link"}