{"product_id":"abcam-ab254267","title":"Abcam, ab254267, Anti-OTP antibody [EPR22178-17]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal OTP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22178-17,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOTP also known as orthopedia homeobox is a transcription factor involved in the development and differentiation of neuroendocrine cells. It belongs to the homeobox family of proteins which are characterized by a specific DNA-binding domain. OTP typically weighs around 35 kDa. This protein is mainly expressed in the central nervous system and neuroendocrine tissues particularly within the hypothalamus.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOTP plays an important role in the regulation of gene expression during the development of specific neuronal cell types. It is not part of a larger complex but interacts with various other transcription factors to influence cell fate decisions. OTP's regulatory actions are essential during embryonic development where it directs the differentiation and specialization of neurons.\u003cbr\u003e\nPathways\u003cbr\u003e\nOTP is significant in the development pathways of the nervous system. It participates in neurogenesis particularly influencing the hypothalamic lineage. OTP interacts with proteins such as Nkx2.1 and Sim1 which are also transcription factors that guide the specification of neuroendocrine neurons. These interactions highlight OTP’s involvement in complex genetic regulatory networks essential for proper nervous system function.\u003cbr\u003e\nOTP shows relevance to certain neurodevelopmental disorders and tumors. Abnormal OTP expression links to the development of medullary thyroid carcinoma a type of cancer affecting thyroid gland cells. Furthermore OTP's expression patterns can aid in distinguishing certain tumor types in neuropathology. Researchers study its interaction with proteins like RET which is also implicated in thyroid cancer to better understand and treat these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850369159337,"sku":"ab254267","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab254267","provider":"Iright","version":"1.0","type":"link"}