{"product_id":"abcam-ab254277","title":"Abcam, ab254277, Anti-Kv1.1 potassium channel antibody [K20\/78] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nMouse Recombinant Monoclonal Kv1.1 potassium channel antibody. Carrier free. Suitable for WB, IHC-P and reacts with Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:K20\/78,\u003cbr\u003e\nIsotype:IgG2b,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab254277 is the carrier-free version of\u003cbr\u003e\nab252537\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Kv1.1 potassium channel also known as Kv1 or Kv1s belongs to the voltage-gated potassium channel family. This channel with molecular mass of approximately 53 kDa plays an important role in the regulation of membrane potential and electrical excitability of neurons. Widely expressed in the central nervous system it is especially present in the nodes of Ranvier and axons of myelinated neurons contributing to the propagation of action potentials.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Kv1.1 channel is essential for controlling neuronal excitability and action potential repolarization. It functions by allowing potassium ions to flow out of the neuron which stabilizes the resting membrane potential. This channel often forms part of a heteromeric complex with other Kv subunits which fine-tune its biophysical properties. Such interactions enable it to modulate synaptic transmission and signal integration in neurons.\u003cbr\u003e\nPathways\u003cbr\u003e\nKv1.1 channels participate in the regulation of the action potential pathway and the synaptic transmission pathway. Through these pathways Kv1.1 interacts with protein partners such as the Kvβ subunits which can modulate the kinetics and voltage dependence of the channel. Its activity contributes significantly to the rapid repolarization of action potentials therefore maintaining the high-frequency firing ability of neurons.\u003cbr\u003e\nAlterations in Kv1.1 channel function are linked to episodic ataxia type 1 and temporal lobe epilepsy. Mutations affecting the channel conductance or gating can lead to disrupted neuronal signaling. In these conditions Kv1.1 has been found to interact with related proteins like Kv1.2 and Kv1.4 which also play roles in neurological function. Understanding the Kv1.1 protein and its interactions is important for developing therapeutic strategies for these channelopathies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855436501161,"sku":"ab254277","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab254277","provider":"Iright","version":"1.0","type":"link"}