{"product_id":"abcam-ab254318","title":"Abcam, ab254318, SIS3, Smad3 inhibitor","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 490 Da, Purity \u0026gt;98%. Potent and selective Smad3 inhibitor. Selectively inhibits TGF-beta 1\/ALK5-induced Smad3 phosphorylation. Inhibits the TGF-beta 1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site. Has no effect on Smad2, p38, MAPK, ERK or PI 3-kinase signaling.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:521984-48-5,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:490 Da,\u003cbr\u003e\nMolecular formula:C28H28ClN3O3,\u003cbr\u003e\nPubChem:16079005,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to \u0026gt;25 mM,\u003cbr\u003e\nBiochemical name:Sis3 HCl,\u003cbr\u003e\nBiological description:Potent and selective Smad3 inhibitor. Selectively inhibits TGF-beta 1\/ALK5-induced Smad3 phosphorylation. Inhibits the TGF-beta 1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site. Has no effect on Smad2, p38, MAPK, ERK or PI 3-kinase signaling.,\u003cbr\u003e\nCanonical smiles:CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl,\u003cbr\u003e\nIsomeric smiles:CN1C(=C(C2=C1N=CC=C2)\/C=C\/C(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl,\u003cbr\u003e\nInChi:InChI=1S\/C28H27N3O3.ClH\/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;\/h4-12,14,16-17H,13,15,18H2,1-3H3;1H\/b12-11+;,\u003cbr\u003e\nInChiKey:CDKIEBFIMCSCBB-CALJPSDSSA-N,\u003cbr\u003e\nIUPAC Name:(E)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one;hydrochloride\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 2227 Smad3 Inhibitor, SIS3. 2227-1 is the same size as the 5 mg size of ab254318.\u003cbr\u003e\nProtect from light and moisture.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847502221481,"sku":"ab254318","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab254318","provider":"Iright","version":"1.0","type":"link"}