{"product_id":"abcam-ab254448","title":"Abcam, ab254448, Galunisertib (LY2157299), TGFB kinase antagonist","description":"\u003cp\u003eSize: 5mg \/ 10mg\u003cbr\u003e\nMW 369.4 Da, Purity \u0026gt;98%. Highly potent, TGF-beta kinase (ALK5) inhibitor (IC 50  = 56 nM). Downregulates Smad2 phosphorylation. Increases VEGF-induced HUVEC cell migration. Enhances anti-neuroblastoma activity of Dinuxtuximab (anti-GD2 antibody) with natural killer cells. Reverses supression of human T cell proliferation induced by TGF-beta and regulatory T cells. Improves tumour growth inhibition and regression in colon carcinoma models. ALK4 and ALK5 (TGFβRI) inhibitor; component of growth media for urothelial organoids.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:700874-72-2,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:369.4 Da,\u003cbr\u003e\nMolecular formula:C22H19N5O,\u003cbr\u003e\nPubChem:10090485,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 50 mM,\u003cbr\u003e\nBiochemical name:Galunisertib,\u003cbr\u003e\nBiological description:Highly potent, TGF-beta kinase (ALK5) inhibitor (IC50 = 56 nM). Downregulates Smad2 phosphorylation. Increases VEGF-induced HUVEC cell migration. Enhances anti-neuroblastoma activity of Dinuxtuximab (anti-GD2 antibody) with natural killer cells. Reverses supression of human T cell proliferation induced by TGF-beta and regulatory T cells. Improves tumour growth inhibition and regression in colon carcinoma models. ALK4 and ALK5 (TGFβRI) inhibitor; component of growth media for urothelial organoids.,\u003cbr\u003e\nCanonical smiles:CC1=NC(=CC=C1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N,\u003cbr\u003e\nInChi:InChI=1S\/C22H19N5O\/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17\/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28),\u003cbr\u003e\nInChiKey:IVRXNBXKWIJUQB-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSolutions in DMSO may be stored at -20°C for up to 1 month.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847501140137,"sku":"ab254448","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab254448","provider":"Iright","version":"1.0","type":"link"}