{"product_id":"abcam-ab254939","title":"Abcam, ab254939, Anti-USP35 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal USP35 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human USP35 aa 600-700.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human USP35 aa 600-700. The exact immunogen used to generate this antibody is proprietary information.Q9P2H5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUSP35 also known as Ubiquitin Specific Peptidase 35 is an enzyme involved in the removal of ubiquitin from ubiquitinated proteins. It functions critically in protein degradation by interacting with the ubiquitin-proteasome system. The molecular weight of USP35 is around 119 kDa. USP35 is expressed in multiple tissues including the brain heart and testis indicating a potential for various biological functions in different organ systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUSP35 plays a role in regulating protein stability and turnover. As part of deubiquitinating enzymes (DUBs) it helps reverse the ubiquitination process that marks proteins for degradation. It contributes to maintaining protein homeostasis which is important for cell function and survival. USP35 may function as part of larger protein complexes although specific complexes have not been definitively described. Its regulatory role can impact cellular processes significantly.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe ubiquitin-proteasome pathway involves USP35 in maintaining protein balance by removing ubiquitin chains. USP35 interacts with other DUBs as well as the proteasome system itself. It is also associated with the ER-associated degradation (ERAD) pathway which controls protein quality in the endoplasmic reticulum. USP35 interacts closely with proteins like HRD1 which is another E3 ubiquitin ligase involved in ERAD highlighting the interconnected nature of protein regulation pathways.\u003cbr\u003e\nUSP35 shows a connection to neurodegenerative disorders such as Parkinson’s disease. Dysregulation of ubiquitin-related processes can lead to an accumulation of misfolded proteins contributing to disease pathogenesis. USP35 may also have a role in cancer where its dysfunction could influence the stability of proteins that control cell growth and apoptosis. Interaction with proteins such as p53 which regulates cell cycle and apoptosis emphasizes the importance of USP35 in maintaining cellular health and preventing disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854173458601,"sku":"ab254939","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab254939","provider":"Iright","version":"1.0","type":"link"}