{"product_id":"abcam-ab255760","title":"Abcam, ab255760, Anti-Caspr2\/CNTNAP2 antibody [K67\/25] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nMouse Recombinant Monoclonal Caspr2\/CNTNAP2 antibody. Carrier free. Suitable for IHC-P and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:K67\/25,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab255760 is the carrier-free version of\u003cbr\u003e\nab252534\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCaspr2 also known as CNTNAP2 is a member of the neurexin family with a molecular mass of approximately 133 kDa. This protein extensively expresses in the nervous system and particularly locates on the axonal membrane. Caspr2 functions as a cell adhesion molecule playing a role in facilitating interactions between neurons and glial cells. Additionally Caspr2 participates in the clustering of ion channels at the nodes of Ranvier which is important for rapid action potential propagation along myelinated axons.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein is important in maintaining the integrity of the neuronal membrane. Caspr2 works as part of a complex associating with contactin proteins to stabilize neuronal networks. It is involved in synaptic plasticity and potentially influences neuronal connectivity and communication. Through its adhesive functions Caspr2 contributes to structural frameworks that ensure proper signal transmission in the neural circuits.\u003cbr\u003e\nPathways\u003cbr\u003e\nCaspr2 participates in pathways responsible for neuronal excitability and membrane potential regulation. It plays an important role within the voltage-gated potassium channel complex. Caspr2 also connects to proteins like TAG-1 forming a vital part of the complex involved in the assembly of potassium channels and ensuring efficient nerve impulse conduction. Its interaction within these pathways impacts synaptic function and cognitive processes by modulating neuronal excitability.\u003cbr\u003e\nCaspr2 has links to epilepsy and autism spectrum disorders where disruptions in its function can lead to pathogenic outcomes. Alterations in Caspr2 expression or structure may result in impaired neuron-glial interactions contributing to neurological symptoms. It relates to contactin-associated proteins in these contexts potentially affecting the development and maintenance of neuronal structures. Understanding Caspr2’s involvement in these diseases helps in developing therapeutic strategies and antibodies such as anti-Caspr2 antibodies to modulate its activity and effects.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855377485993,"sku":"ab255760","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab255760","provider":"Iright","version":"1.0","type":"link"}