{"product_id":"abcam-ab259943","title":"Abcam, ab259943, Anti-PCGF1 antibody [EPR23757-38]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal PCGF1 antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Mouse, Human, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23757-38,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IP, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPCGF1 also known as Polycomb group RING finger protein 1 is a component of the Polycomb Group (PcG) proteins. It has a mass of approximately 36 kDa. This protein functions mechanically as part of the Polycomb Repressive Complex 1 (PRC1) where it plays a role in chromatin modification and gene silencing. PCGF1 is expressed in various tissues including embryonic stem cells and can affect cellular differentiation and proliferation through epigenetic regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPCGF1 serves as a regulatory factor within the Polycomb Repressive Complex 1 which is involved in maintaining the transcriptionally repressive state of many genes through histone modifications. PCGF1 assists in the ubiquitination of histone H2A an essential modification for chromatin conformation that leads to transcriptional repression. Through this modification PCGF1 contributes to the control of gene networks necessary for development and cellular identity.\u003cbr\u003e\nPathways\u003cbr\u003e\nPCGF1 is a part of the Polycomb Repressive Complex 1 pathway and contributes to the intricate network of gene expression regulation. The complex participates in the Wnt signaling pathway which plays a critical role in embryonic development and cell growth. Through its participation in these pathways PCGF1 interacts with other proteins like BMI1 and RING1 which help in establishing transcriptional repression important for proper cellular function.\u003cbr\u003e\nAlterations in PCGF1 have been linked to certain cancers and neurological disorders. Dysregulation of PCGF1 expression or function can lead to aberrant cell proliferation contributing to oncogenesis in cancers such as leukemia. Moreover defects in the PcG pathway involving PCGF1 are associated with neurodevelopmental disorders where altered expression patterns of target genes disrupt normal neural function. These conditions highlight the connections between PCGF1 and proteins like EED and SUZ12 which also play roles in the regulation of gene expression and are implicated in similar disease processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850352644265,"sku":"ab259943","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab259943","provider":"Iright","version":"1.0","type":"link"}