{"product_id":"abcam-ab259968","title":"Abcam, ab259968, Anti-SIRT7 antibody [EPR23811-15]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SIRT7 antibody. Suitable for IHC-P, IP, WB and reacts with Mouse, Rat, Human samples. Cited in 17 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23811-15,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSIRT7 also known as sirtuin 7 is a member of the sirtuin family of proteins which are class III histone deacetylases. SIRT7 has an approximate mass of 44 kDa and primarily resides in the nucleolus where it is involved in the regulation of ribosomal DNA transcription. It acts by removing acetyl groups from histone H3 at lysine 18 (H3K18Ac) which impacts chromatin structure and gene expression. SIRT7 expression is found in various tissues with higher levels observed in metabolically active tissues such as the liver heart and kidneys.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSIRT7 plays a significant role in cell proliferation stress resistance and metabolism. It is a component of a nucleolar complex that actively regulates RNA polymerase I-dependent transcription. By deacetylating target substrates SIRT7 enhances rRNA synthesis which is vital for ribosome biogenesis and cellular growth. Additionally SIRT7 influences various cellular processes including mitochondrial homeostasis and DNA damage repair through its deacetylase activity on both histones and non-histone proteins.\u003cbr\u003e\nPathways\u003cbr\u003e\nSIRT7 integrates into the broader framework of cellular regulatory mechanisms. Specifically it is involved in the aging pathway and the p53 signaling pathway. In the aging pathway SIRT7 functions alongside related sirtuins like SIRT1 to modulate lifespan and stress responses. In the p53 signaling pathway SIRT7 interacts with proteins such as p53 and MDM2 influencing apoptosis and cell cycle regulation. These pathways reflect its adaptability in managing cellular survival and growth responses.\u003cbr\u003e\nSIRT7's involvement is highlighted in cancer and cardiovascular diseases. In cancer its role in promoting ribosomal biogenesis and cell proliferation links it to tumor progression where overexpression correlates with certain cancer types. SIRT7 interacts with oncogenes and tumor suppressor proteins such as MYC and p53 modulating their pathways. In cardiovascular disorders altered SIRT7 activity affects cardiac hypertrophy and myocardial function with connections to proteins that regulate cardiac stress responses such as AMPK and PGC-1α. These associations demonstrate SIRT7’s significant impact on disease development and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850206826665,"sku":"ab259968","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab259968","provider":"Iright","version":"1.0","type":"link"}