{"product_id":"abcam-ab26322","title":"Abcam, ab26322, Anti-cAMP Protein Kinase Catalytic subunit antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal cAMP Protein Kinase Catalytic subunit antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Chinese hamster, Mouse, Rat, Human, Guinea pig, Pig samples. Cited in 25 publications. Immunogen corresponding to Synthetic Peptide within Human PRKACA aa 300-350 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human, Guinea pig, Pig, Chinese hamster,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human PRKACA aa 300-350 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P17612\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe cAMP Protein Kinase Catalytic subunit also known as protein kinase A (PKA) catalytic subunit plays an important role as an enzyme that phosphorylates various target proteins. This is an important component of the protein kinase A signaling pathway. The subunit has an approximate mass of 40 kDa and is widely expressed in multiple tissues across the body allowing it to affect numerous physiological functions. As a catalytic subunit of cAMP-dependent protein kinase it forms part of the larger enzyme complex that is activated by the binding of cAMP.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe catalytic subunit of protein kinase A modulates cellular processes by transferring a phosphate group from ATP to specific serine\/threonine residues on substrates. It is part of a holoenzyme complex composed of two regulatory and two catalytic subunits; when cAMP binds to the regulatory subunits it releases the catalytic subunits allowing them to execute their activity. This release and activation result in the regulation of glycogen sugar and lipid metabolism among others.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe cAMP Protein Kinase integrates deeply into the cAMP signaling and MAPK\/ERK pathways. These pathways regulate various processes like cell growth differentiation and apoptosis. The catalytic subunit acts downstream of cAMP generation by adenylyl cyclase interacting with other proteins such as CREB (cAMP response element-binding protein) which directly affects transcription and gene expression.\u003cbr\u003e\nThe cAMP Protein Kinase catalytic subunit has been linked to conditions including Carney complex and Cushing’s syndrome. Mutations affecting this subunit can lead to dysregulated cAMP signaling impacting proteins like regulatory subunit PRKAR1A that are important in controlling PKA activity. Conditions such as these often arise from aberrations in cAMP signaling pathways reflecting the extensive influence of the cAMP Protein Kinase on homeostasis and disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854128631977,"sku":"ab26322","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab26322","provider":"Iright","version":"1.0","type":"link"}