{"product_id":"abcam-ab265234","title":"Abcam, ab265234, Human EMC2 (TTC35) knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nEMC2 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 4 bp deletion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 4 bp deletion in exon 1,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-EMC2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTTC35 also known as tetratricopeptide repeat protein 35 plays a mechanical role in cellular processes. This protein weighs approximately 35 kDa and is expressed in many human tissues including the liver and kidney. Researchers have identified TTC35 through its essential tetratricopeptide repeat domains which facilitate protein-protein interactions important for cellular homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAs an integral component of multiple intracellular complexes TTC35 influences protein folding and stability. TTC35 has been found in the context of chaperone protein complexes where it assists in the maintenance of proper protein conformation. This effect on protein conformation plays a direct role in preventing protein aggregation which can be harmful to cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nTTC35 impacts molecular pathways involved in protein quality control and stress responses. It intersects with pathways like the unfolded protein response (UPR) and is linked to proteins such as HSP70 a critical player in cellular stress management. TTC35's involvement in these pathways helps ensure that proteins remain correctly folded and functional under stressful conditions.\u003cbr\u003e\nTTC35's alteration associates with neurodegenerative diseases including Alzheimer's disease and Huntington's disease. Misregulation of TTC35 or its pathway components like HSP70 can result in protein misfolding and aggregation contributing to disease progression. Undoubtedly understanding TTC35's role in these contexts opens the door to potential therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845207609513,"sku":"ab265234","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab265234","provider":"Iright","version":"1.0","type":"link"}