{"product_id":"abcam-ab265746","title":"Abcam, ab265746, Human HMGN4 knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nHMGN4 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 1 bp insertion in exon 2 and 31 bp deletion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 1 bp insertion in exon 2 and 31 bp deletion in exon 2,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-HMGN4, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHMGN4 also known as High Mobility Group Nucleosome Binding Domain 4 is a chromosomal protein with an approximate mass of 12 kDa. This protein functions mechanically by binding to nucleosomes altering the chromatin structure and influencing gene expression. It is expressed in various tissues with higher levels found in the brain and testis. HMGN4 plays roles in regulating the dynamics of chromatin impacting accessibility and stability of DNA.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHMGN4 modulates transcriptional activity by altering the chromatin compaction state not working as a part of a complex. It influences how genes are turned on or off impacting cellular processes such as differentiation and proliferation. This modulation occurs through its interaction with nucleosomes positioning it as an important factor in the control of gene regulatory mechanisms across different cell types.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers study HMGN4 to understand its involvement in transcriptional regulation and DNA repair pathways. These pathways guide critical cellular activities affecting how cells respond to damage and manage genetic information. HMGN4 interacts with proteins like histone H1 an important player in facilitating chromatin remodeling which supports effective gene regulation and maintains genomic integrity.\u003cbr\u003e\nResearchers associate HMGN4 with certain types of cancer and neurological disorders. Aberrant expression levels of HMGN4 have links to tumor progression as altered chromatin states may lead to deregulation of oncogenes. The protein connects to Alzheimer's disease through its influence on neuronal gene expression implicating interactions with tau proteins. These associations highlight HMGN4 as a potential target for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845150232745,"sku":"ab265746","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab265746","provider":"Iright","version":"1.0","type":"link"}